Cannabis and nicotine together have notably different effects on the brain than either of them taken on their own. That’s the conclusion of US researchers who noted that cannabis is commonly consumed in conjunction with tobacco.

According to their study, participants who used only nicotine or only cannabis showed less functional connectivity than those who took both together.

The study results were published this month in the journal Brain Structure and Function by researchers at the University of Texas at Dallas.

In their article “Differential associations of combined vs. isolated cannabis and nicotine on brain resting state networks”, the researchers say much of the existing research on cannabis neglects the dual-use issue. Yet their research shows a clear difference in the impact on the brain of using cannabis alone or in combination with nicotine.

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